The NSA recommends creating separate partitions for /boot, /, /home, /tmp, and /var/tmp. The reasons for each are different and we will address each partition.

/boot - This partition is the first partition that is read by the system during boot up. The boot loader and kernel images that are used to boot your system into Fedora are stored in this partition. This partition should not be encrypted. If this partition is included in / and that partition is encrypted or otherwise becomes unavailable then your system will not be able to boot.

/home - When user data (/home) is stored in / instead of in a separate partition, the partition can fill up causing the operating system to become unstable. Also, when upgrading your system to the next version of Fedora it is a lot easier when you can keep your data in the /home partition as it will not be overwritten during installation. If the root partition (/) becomes corrupt your data could be lost forever. By using a separate partition there is slightly more protection against data loss. You can also target this partition for frequent backups.

/tmp and /var/tmp - Both the /tmp and the /var/tmp directories are used to store data that doesn't need to be stored for a long period of time. However if a lot of data floods one of these directories it can consume all of your storage space. If this happens and these directories are stored within / then your system could become unstable and crash. For this reason, moving these directories into their own partitions is a good idea.